4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

Base Information

Chemical Name:4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide
CAS No.:245118-90-5
Molecular Formula:C₂₈H₃₅N₃O₆S
Molecular Weight:541.668
Hs Code.:

4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-<i>N</i>-[6-(2-hydroxy-ethoxy)-5-<i>p</i>-tolyl-pyrimidin-4-yl]-benzenesulfonamide

Synonyms:4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

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Chemical Property of 4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

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Technology Process of 4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

There total 8 articles about 4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 245118-90-5
4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

2: NaH / 48 h / 110 °C

With (1S)-10-camphorsulfonic acid; sodium hydride; In dichloromethane;
DOI:10.1021/jm000538f

Reference yield:

: 2901-13-5
ethyl 2-methyl-2-phenylpropionate

: 245118-90-5
4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: ClSO₃H / CH₂Cl₂ / 22 h / 20 °C

2: 1.56 g / aq. NH₄OH / ethyl acetate / 2 h / 20 °C

3: 94 percent / aq. NaOH / methanol / 22 h / 20 °C

4: 98 percent / NaBH₄; BF₃*Et₂O / tetrahydrofuran / 3 h / 20 °C

5: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

6: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

7: NaH / 48 h / 110 °C

With chlorosulfonic acid; ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm000538f

Reference yield:

: 374067-96-6
4-(2-hydroxy-1,1-dimethylethyl)benzenesulfonamide

: 245118-90-5
4-[1,1-dimethyl-2-(tetrahydro-pyran-2-yloxy)-ethyl]-N-[6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / K₂CO₃ / dimethylsulfoxide / 1.5 h / 80 °C

2: 83 percent / 10-camphorsulfonic acid / CH₂Cl₂ / 1.5 h / 20 °C

3: NaH / 48 h / 110 °C

With (1S)-10-camphorsulfonic acid; sodium hydride; potassium carbonate; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm000538f