N-[1,4,5,6,7,8-Hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-propanamide

Base Information

• Chemical Name: N-[1,4,5,6,7,8-Hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-propanamide
• CAS No.: 172758-08-6
• Molecular Formula: C18H22 N6 O3
• Molecular Weight: 370.40568
• Mol file: 172758-08-6.mol

Synonyms:Propanamide,N-[1,4,5,6,7,8-hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-(9CI)

Chemical Property of N-[1,4,5,6,7,8-Hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-propanamide

Chemical Property:

• Melting Point: >300 °C
• Refractive Index: 1.687
• PKA: 9.42±0.60(Predicted)
• PSA: 123.83000
• Density: 1.42g/cm³
• LogP: 2.87350

Purity/Quality:

95% ^*data from raw suppliers

N-[1,4,5,6,7,8-HEXAHYDRO-6,7-DIMETHYL-4-OXO-5-(3-PYRIDINYLCARBONYL)-2-PTERIDINYL]-2-METHYL-PROPANAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[1,4,5,6,7,8-Hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-propanamide

There total 1 articles about N-[1,4,5,6,7,8-Hexahydro-6,7-dimethyl-4-oxo-5-(3-pyridinylcarbonyl)-2-pteridinyl]-2-methyl-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C12H19N5O2 (109132-71-0) + pyridine-3-carbonyl chloride hydrochloride (20260-53-1) → N2-isobutyroyl-6,7-dimethyl-5-nicotinoyl-5,6,7,8-tetrahydropterin (172758-08-6)

Guidance literature:

With pyridine;

DOI:10.3987/COM-08-S(F)70

Reference yield: 88.0%

N2-isobutyroyl-6,7-dimethyl-5-nicotinoyl-5,6,7,8-tetrahydropterin (172758-08-6) + benzyl bromide (100-39-0) → N2-isobutyroyl-6,7-dimethyl-5-(I-benzylnicotinoylium)-5,6,7,8-tetrahydropterin bromide (172758-14-4)

Guidance literature:

In dimethyl sulfoxide; at 20 ℃; for 12h;

DOI:10.3987/COM-08-S(F)70

Reference yield: 88.0%

amyl iodide (628-17-1) + N2-isobutyroyl-6,7-dimethyl-5-nicotinoyl-5,6,7,8-tetrahydropterin (172758-08-6) → N2-isobutyroyl-6,7-dimethyl-5-(1-n-pentylnicotinoylium)-5,6,7,8-tetrahydropterin iodide (1147330-05-9)

Guidance literature:

In N,N-dimethyl-formamide; at 150 ℃; for 4h;

DOI:10.3987/COM-08-S(F)70

upstream raw materials:

C₁₂H₁₉N₅O₂

pyridine-3-carbonyl chloride hydrochloride

Downstream raw materials:

N2-isobutyroyl-6,7-dimethyl-5-(1-n-pentylnicotinoylium)-5,6,7,8-tetrahydropterin iodide

N₂-isobutyroyl-6,7-dimethyl-5-(I-benzylnicotinoylium)-5,6,7,8-tetrahydropterin bromide

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