ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

Base Information

Chemical Name:ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate
CAS No.:150058-12-1
Molecular Formula:C₂₈H₂₇N₃O₂
Molecular Weight:437.541
Hs Code.:

Synonyms:ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

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Chemical Property of ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

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Technology Process of ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

There total 9 articles about ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1519-23-9
2-methylbutanoic anhydride

: 136285-69-3
ethyl 3-amino-2-<<(2'-cyanobiphenyl-4-yl)methyl>amino>benzoate

: 150058-12-1
ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

Guidance literature:: With pyridine; at 115 ℃; for 15h;
DOI:10.1021/jm00067a016

Reference yield:

: 21606-04-2
methyl 2-carboxy-3-nitrobenzoate

: 150058-12-1
ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: SOCl₂, DMF / toluene / 0.5 h / Heating

2: NaN₃ / acetone; H₂O / 1 h

3: 1.5 h / Heating

4: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

6: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

7: 78 percent / ethanol / 1.5 h / Heating

8: 92 percent / pyridine / 15 h / 115 °C

With pyridine; hydrogenchloride; thionyl chloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; N,N-dimethyl-formamide; In ethanol; water; ethyl acetate; acetone; toluene; acetonitrile;
DOI:10.1021/jm00067a016

Reference yield:

: 73833-13-3
acid chloride of 1-methylhydrogen-3-nitrophthalate

: 150058-12-1
ethyl 1-<(2'-cyanobiphenyl-4-yl)methyl>-2-(2-methylpropyl)-1H-benzimidazole-7-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: NaN₃ / acetone; H₂O / 1 h

2: 1.5 h / Heating

3: 85 percent / K₂CO₃ / acetonitrile / 4 h / Heating

4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature

5: 1.) FeCl₃*6H₂O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h

6: 78 percent / ethanol / 1.5 h / Heating

7: 92 percent / pyridine / 15 h / 115 °C

With pyridine; hydrogenchloride; sodium azide; potassium carbonate; pyrographite; hydrazine hydrate; In ethanol; water; ethyl acetate; acetone; acetonitrile;
DOI:10.1021/jm00067a016