tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate

Base Information

• Chemical Name: tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate
• CAS No.: 256478-16-7
• Molecular Formula: C₂₁H₂₂ClN₅O₄S
• Molecular Weight: 475.956
• Mol file: 256478-16-7.mol

Synonyms:tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate

Chemical Property of tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate

There total 9 articles about tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2-nitrobenzoate (55666-41-6) → tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate (256478-16-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 4.0 g / H₂ / Pd/C / ethanol / 4 h / 23 °C / 3102.97 Torr

2.1: 120 mg / NEt₃ / CH₂Cl₂ / 6 h / Heating

3.1: NaH / dimethylsulfoxide / 0.5 h / 60 °C

3.2: 30 mg / dimethylsulfoxide / 24 h / 100 °C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm061066t

Reference yield:

2-nitrobenzyl chloride (610-14-0) → tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate (256478-16-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 4.9 g / 3 h / Heating

2.1: 4.0 g / H₂ / Pd/C / ethanol / 4 h / 23 °C / 3102.97 Torr

3.1: 120 mg / NEt₃ / CH₂Cl₂ / 6 h / Heating

4.1: NaH / dimethylsulfoxide / 0.5 h / 60 °C

4.2: 30 mg / dimethylsulfoxide / 24 h / 100 °C

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; dimethyl sulfoxide;

DOI:10.1021/jm061066t

Reference yield:

tert-butyl 2-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate (256477-24-4) + guanidine hydrochloride (50-01-1) → tert-butyl 2-{[(4-chloro-1-guanidino-7-isoquinolinyl)sulphonyl]amino}benzoate (256478-16-7)

Guidance literature:

guanidine hydrochloride; With sodium hydride; In dimethyl sulfoxide; at 60 ℃; for 0.5h;

tert-butyl 2-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate; In dimethyl sulfoxide; at 100 ℃; for 24h; Further stages.;

DOI:10.1021/jm061066t

upstream raw materials:

tert-butyl 2-{[(1,4-dichloro-7-isoquinolinyl)sulphonyl]amino}benzoate

guanidine hydrochloride

4-chloro-1-oxo-1,2-dihydro-7-isoquinolinesulfonyl chloride

1,4-dichloro-7-isoquinolinesulphonyl chloride