tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate
CAS No.:960391-37-1
Molecular Formula:C₂₈H₄₀F₂N₄O₃
Molecular Weight:518.647
Hs Code.:

Synonyms:tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

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Technology Process of tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

There total 7 articles about tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 960391-21-3
2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazole-5-carboxylic acid

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 960391-37-1
tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 809273-65-2
(4,4-difluorocyclohexane)methylamine hydrochloride

: 960391-37-1
tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

3.1: dmap / dichloromethane / 4 h / 20 °C

4.1: acetic acid / 3 h / 150 °C / Microwave irradiation

5.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

5.2: pH 5 - 6

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 809273-66-3
methyl {[(4,4-difluorocyclohexyl)methanol]amino}-3-nitrobenzoate

: 960391-37-1
tert-butyl 4-({2-tert-butyl-1-[(4,4-difluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}carbonyl)piperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C / 2585.81 Torr

2.1: dmap / dichloromethane / 4 h / 20 °C

3.1: acetic acid / 3 h / 150 °C / Microwave irradiation

4.1: lithium hydroxide; water / 1,4-dioxane / 3 h / 75 °C

4.2: pH 5 - 6

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h / 20 °C

With dmap; lithium hydroxide; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;