4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane

Base Information

• Chemical Name: 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane
• CAS No.: 179989-93-6
• Molecular Formula: C₁₁H₁₆BP
• Molecular Weight: 190.033
• Mol file: 179989-93-6.mol

Synonyms:4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane

Chemical Property of 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane

Chemical Property:

Purity/Quality:

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Technology Process of 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane

There total 15 articles about 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethylsulfide borane complex (13292-87-0) + 3-Methyl-1-phenyl-2-phospholene 1-oxide (707-61-9) → 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane (179989-93-6)

Guidance literature:

With trichlorosilane; In dichloromethane; N2-atmosphere; addn. of slight excess Me3SiH to oxide at 0°C, stirring for 6 h, removal of volatiles (vac.), addn. of equimolar amt. of borane at 0°C, stirring for 6 h; filtration, evapn.;

DOI:10.1016/0022-328X(96)06134-7

Reference yield: 46.0%

(R)-ethenyl(3-methylbut-3-en-1-yl)phenylphosphine borane (1416656-03-5,1416896-15-5) → (R)-4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane (1416896-13-3,179989-93-6)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ol303253h

Reference yield: 40.0%

lithium borohydride + 1-chloro-3-methyl-1-phenyl-2-phospholenium salt (17154-12-0) → 4-methyl-1-phenyl-2,3-dihydro-1H-phosphol-1-ane borane (179989-93-6)

Guidance literature:

In tetrahydrofuran; dichloromethane; at 0 - 26 ℃; for 24.25h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.12.059

upstream raw materials:

dimethylsulfide borane complex

3-Methyl-1-phenyl-2-phospholene 1-oxide

2-boranyl(3-methylbut-3-en-1-yl)(phenylphosphaniumyl)ethan-1-ol

ethenyl(3-methylbut-3-en-1-yl)phenylphosphine borane

Downstream raw materials:

4-methyl-1-phenyl-2,3-dihydro-1H-phosphole-dichloromethylborane

6,6-dichloro-1-methyl-4-phenyl-4-phosphabicyclo[3.1.0]hexane-dichloromethylborane

3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-phosphole-dichloromethylborane