2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde

Base Information

• Chemical Name: 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde
• CAS No.: 473240-36-7
• Molecular Formula: C₂₆H₂₂O₇
• Molecular Weight: 446.456
• Mol file: 473240-36-7.mol

Synonyms:2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde

Chemical Property of 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde

There total 1 articles about 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-benzyloxy-3-methoxy-phenyl)-5-(5,5-dimethyl-[1,3]dioxan-2-yl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester; compound with mercury(II) chloride → 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde (473240-36-7)

Guidance literature:

With hydrogenchloride; In acetone; at 20 ℃; for 4h;

DOI:10.1021/jo0258960

Reference yield: 78.0%

(carbethoxymethyl)triphenylphosphonium bromide (1530-45-6) + 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde (473240-36-7) → 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester (213970-74-2)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1021/jo0258960

Reference yield:

2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde (473240-36-7) → 5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde (135040-83-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 3 h / -78 °C

2: 49 percent / DIBAL-H / tetrahydrofuran; CH₂Cl₂ / 1.5 h / 20 °C

3: hydrogen / 10percent Pd-C / ethanol / 15 h / 20 °C

4: 154 mg / active MnO₂ / CH₂Cl₂ / 5 h / 20 °C

With manganese(IV) oxide; hydrogen; diisobutylaluminium hydride; 10percent Pd-C; In tetrahydrofuran; ethanol; dichloromethane; 1: Wittig reaction;

DOI:10.1021/jo0258960

Downstream raw materials:

2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde

2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

(E)-2-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-5-(3-hydroxyprop-1-en-1-yl)-7-methoxybenzofuran