2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

Base Information

• Chemical Name: 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester
• CAS No.: 213970-74-2
• Molecular Formula: C₃₀H₂₈O₈
• Molecular Weight: 516.548

Synonyms:2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

Chemical Property of 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

There total 7 articles about 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(carbethoxymethyl)triphenylphosphonium bromide (1530-45-6) + 2-(4-benzyloxy-3-methoxyphenyl)-3-methoxycarbonyl-7-methoxybenzofuran-5-carboxaldehyde (473240-36-7) → 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester (213970-74-2)

Guidance literature:

In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1021/jo0258960

Reference yield: 68.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + (E)-3-[3-(4-Benzyloxy-3-methoxy-phenylethynyl)-4-hydroxy-5-methoxy-phenyl]-acrylic acid ethyl ester (213970-73-1) → 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester (213970-74-2)

Guidance literature:

With sodium acetate; copper dichloride; palladium dichloride;

DOI:10.1055/s-1999-2764

Reference yield:

methanol (67-56-1) + carbon monoxide (201230-82-2) + (E)-3-[3-(4-Benzyloxy-3-methoxy-phenylethynyl)-4-hydroxy-5-methoxy-phenyl]-acrylic acid ethyl ester (213970-73-1) → 2-(4-Benzyloxy-3-methoxy-phenyl)-5-((E)-2-ethoxycarbonyl-vinyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester (213970-74-2) + 5-(2-(ethoxycarbonyl)-E-ethenyl)-7-methoxy-2-(3-methoxy-4-benzyloxyphenyl)benzofuran (213970-70-8)

Guidance literature:

With sodium acetate; palladium diacetate; for 5h; under 760 Torr;

DOI:10.1016/S0040-4039(98)01371-9

upstream raw materials:

methanol

carbon monoxide

(E)-3-[3-(4-Benzyloxy-3-methoxy-phenylethynyl)-4-hydroxy-5-methoxy-phenyl]-acrylic acid ethyl ester

(carbethoxymethyl)triphenylphosphonium bromide

Downstream raw materials:

(E)-2-(4-benzyloxy-3-methoxyphenyl)-3-hydroxymethyl-5-(3-hydroxyprop-1-en-1-yl)-7-methoxybenzofuran

2-(3-methoxy-4-hydroxyphenyl)-3-methoxycarbonyl-5-(3-hydroxypropyl)-7-methoxybenzo[b]furan

5-(3-hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)-3-benzo[b]furan-carbaldehyde

5-(2-Ethoxycarbonyl-ethyl)-2-(4-hydroxy-3-methoxy-phenyl)-7-methoxy-benzofuran-3-carboxylic acid methyl ester

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