(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

Base Information Edit

Chemical Name:(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt
CAS No.:60445-97-8
Molecular Formula:C₁₀H₁₆N*C₂₆H₃₃N₆O₅S₂
Molecular Weight:723.961
Hs Code.:
Mol file:60445-97-8.mol

(6<i>R</i>)-7<i>t</i>-(3,5-di-<i>tert</i>-butyl-4-hydroxy-benzylideneamino)-7<i>c</i>-methoxy-3-(1-methyl-1<i>H</i>-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6<i>r</i><i>H</i>)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

Synonyms:(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

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Chemical Property of (6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt Edit

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Technology Process of (6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

There total 1 articles about (6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865-34-9
lithium methanolate

: 100-85-6
N-benzyl-trimethylammonium hydroxide

: 24209-38-9
(6R,7R)-7-amino-3-[(1H-1-methyltetrazol-5-yl)thio]methylceph-3-em-4-carboxylic acid

: 1620-98-0
3,5-di-t-butyl-4-hydroxybenzaldehyde

: 60445-97-8
(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

Guidance literature:: Multistep reaction; (i) MeOH, THF, (ii) /BRN= 982526/, (iii) /BRN= 3552389/, tBuOCl, ClCH₂CH₂Cl;
DOI:10.7164/antibiotics.29.969

Reference yield:

: 60445-97-8
(6R)-7t-(3,5-di-tert-butyl-4-hydroxy-benzylideneamino)-7c-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; benzyl-trimethyl-ammonium salt

: 56796-20-4,82263-66-9
Cefmetazole

Guidance literature:: Multi-step reaction with 2 steps

1: PhNHNH₂ / 1,2-dichloro-ethane

2: PhNEt₂ / 1,2-dichloro-ethane

With phenylhydrazine; N,N-diethylaniline; In 1,2-dichloro-ethane;
DOI:10.7164/antibiotics.29.969