1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone
CAS No.:204329-81-7
Molecular Formula:C₁₇H₂₅F₃O₂Si
Molecular Weight:346.465
Hs Code.:

Synonyms:1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

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Chemical Property of 1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

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Technology Process of 1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

There total 6 articles about 1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 383-63-1
ethyl trifluoroacetate,

: 153993-80-7
[3-(4-bromophenyl)propoxy](tert-butyl)dimethylsilane

: 204329-81-7
1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

Guidance literature:: With n-butyllithium; In diethyl ether; at -42 ℃; 1.) -42 -> 0 deg C;
DOI:10.1246/cl.1998.203

Reference yield: 76.0%

: 340-07-8
N-(trifluoroacetyl)piperidine

: 153993-80-7
[3-(4-bromophenyl)propoxy](tert-butyl)dimethylsilane

: 204329-81-7
1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

Guidance literature:: [3-(4-bromophenyl)propoxy](tert-butyl)dimethylsilane; With n-butyllithium; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; Inert atmosphere;

N-(trifluoroacetyl)piperidine; In tetrahydrofuran; diethyl ether; at -78 - 0 ℃; for 2h; Inert atmosphere;
DOI:10.1002/ejoc.200901385

Reference yield:

: 25574-11-2
3-(4-bromophenyl)propanol

: 204329-81-7
1-{4-[3-(tert-butyldimethylsilyloxy)propyl]phenyl}-2,2,2-trifluoroethanone

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / dimethylformamide

2: 79 percent / 1.) n-BuLi / diethyl ether / -42 °C / 1.) -42 -> 0 deg C

With 1H-imidazole; n-butyllithium; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1246/cl.1998.203