1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

Base Information

• Chemical Name: 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine
• CAS No.: 365213-42-9
• Molecular Formula: C₁₇H₁₉N₃O
• Molecular Weight: 281.357
• Mol file: 365213-42-9.mol

Synonyms:1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property of 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine

There total 2 articles about 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-(4-methoxyphenyl)imidazo[1,2-a]pyridine (31562-99-9) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (365213-42-9)

Guidance literature:

With tert.-butylhydroperoxide; copper(II) bis(trifluoromethanesulfonate); In decane; at 90 ℃; for 12h;

DOI:10.1016/j.tetlet.2020.152581

Reference yield: 85.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-(4-methoxyphenyl)imidazo[1,2-a]pyridine (31562-99-9) + dimethyl amine (124-40-3) → 1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (365213-42-9)

Guidance literature:

With acetic acid; In water; at 50 - 55 ℃; for 4h;

Reference yield:

1-(2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-dimethylmethanamine (365213-42-9) → 2-[2-(4-methoxy-phenyl)-imidazo[1,2-a]pyridin-3-yl]-N,N-dimethyl-acetamide

Guidance literature:

Multi-step reaction with 3 steps

1.1: MeI / CH₂Cl₂ / 24 h / 20 °C

1.2: H₂O / 4 h / Heating

2.1: 82 percent / aq. KOH / ethanol / 8 h / Heating

3.1: 72 percent / tetrahydrofuran / 1 h / 20 °C

With potassium hydroxide; methyl iodide; In tetrahydrofuran; ethanol; dichloromethane;

upstream raw materials:

formaldehyd

2-(4-methoxyphenyl)imidazo[1,2-a]pyridine

dimethyl amine

N,N-dimethyl-formamide

Downstream raw materials:

[2-(4-methoxyphenyl)imidazo[1,2-a]pyridin-3-yl]acetic acid