C₄₈H₅₂Cl₂N₁₂O₆

Base Information

• Chemical Name: C₄₈H₅₂Cl₂N₁₂O₆
• CAS No.: 1595051-11-8
• Molecular Formula: C₄₈H₅₂Cl₂N₁₂O₆
• Molecular Weight: 963.924
• Mol file: 1595051-11-8.mol

Synonyms:C₄₈H₅₂Cl₂N₁₂O₆

Chemical Property of C₄₈H₅₂Cl₂N₁₂O₆

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₈H₅₂Cl₂N₁₂O₆

There total 11 articles about C₄₈H₅₂Cl₂N₁₂O₆ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C58H68Cl2N12O10 → C48H52Cl2N12O6 (1595051-11-8)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja5014344

Reference yield:

chlorambucil (305-03-3) → C48H52Cl2N12O6 (1595051-11-8)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride / dichloromethane / 0 °C / Inert atmosphere

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 0 °C / Inert atmosphere

4: trifluoroacetic acid / dichloromethane

With thionyl chloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; trifluoroacetic acid; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/ja5014344

Reference yield:

N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide (1595051-08-3) → C48H52Cl2N12O6 (1595051-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium L-ascorbate; copper(ll) sulfate pentahydrate / water; tert-butyl alcohol / 0 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; trifluoroacetic acid; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/ja5014344

upstream raw materials:

N-(2-azidoethyl)-4-(4-(bis(2-chloroethyl)amino)phenyl)butanamide

dimethyl 4-hydroxypyridine-2,6-dicarboxylate

chlorambucil

chlorambucil chloride