2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Base Information

Chemical Name:2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide
CAS No.:177559-73-8
Molecular Formula:C₂₆H₂₄N₂O₃
Molecular Weight:412.488
Hs Code.:

Synonyms:2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Suppliers and Price of 2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

There total 7 articles about 2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 177559-73-8
2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:

Reference yield:

: (3-Biphenyl-2-ylmethyl-2-ethyl-7-methoxy-indolizin-1-yl)-oxo-acetyl chloride

: 177559-73-8
2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm960395q

Reference yield:

: 24103-75-1
4-methoxy-2-methylpyridine

: 177559-73-8
2-(2-ethyl-7-methoxy-3-(o-phenylbenzyl)indolizin-1-yl)glyoxylylamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethyl acetate / 0.5 h / 70 °C

2: 1,8-diazabicyclo<5.4.0>undec-7-ene / benzene / 0.75 h / Heating

3: 90.2 percent / benzene / 4 h / Heating

4: 39.2 percent / BH₃, t-BuNH₂, AlCl₃ / CH₂Cl₂ / 5 h

5: tetrahydrofuran / 1 h / 0 °C

6: aq. NH₄OH / tetrahydrofuran / 1 h / Ambient temperature

With ammonium hydroxide; aluminium trichloride; borane; 1,8-diazabicyclo[5.4.0]undec-7-ene; tert-butylamine; In tetrahydrofuran; dichloromethane; ethyl acetate; benzene;
DOI:10.1021/jm960395q