(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

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Chemical Name:(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt
CAS No.:1173157-81-7
Molecular Formula:CH₂O₂*C₂₃H₃₁N₃O₄
Molecular Weight:459.543
Hs Code.:

Synonyms:(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

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Chemical Property of (2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

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Technology Process of (2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

There total 10 articles about (2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.8%

: 64-18-6
formic acid

: 1173157-83-9
C₂₇H₃₅N₃O₆

: 1173157-81-7
(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

Guidance literature:: C₂₇H₃₅N₃O₆; With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; diethylamine; In water; acetonitrile; at 22 ℃; for 1h;

formic acid; In water;

Reference yield:

: 943-73-7
D-homophenylalanine

: 1173157-81-7
(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium carbonate / water; tetrahydrofuran / 1 h / 22 °C

1.2: pH 3 - 4

2.1: methanol / dichloromethane; diethyl ether / 0.5 h / 22 °C

3.1: hydroxylamine hydrochloride; potassium hydroxide / methanol / 0 - 22 °C

4.1: potassium carbonate / ethanol; water / 1 h / 22 °C

5.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 1 h / 22 °C

With methanol; hydroxylamine hydrochloride; sodium carbonate; potassium carbonate; diethylamine; potassium hydroxide; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173157-81-7
(2S)-N-{[4-(aminomethyl)phenyl]methoxy}-2-[(tert-butoxy)carbonylamino]-4-phenylbutanamide formic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.58 h / 0 - 22 °C

4.1: potassium carbonate / ethanol; water / 1 h / 22 °C

5.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 1 h / 22 °C

With lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;