(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

Base Information

Chemical Name:(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate
CAS No.:1415336-43-4
Molecular Formula:C₂₀H₃₀N₂O₄S₂
Molecular Weight:426.601
Hs Code.:

Synonyms:(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

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Technology Process of (R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

There total 6 articles about (R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1415336-42-3
(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

: 1415336-43-4
(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

Guidance literature:: With piperidine; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-56-9
methyl 5-[2-(2-amino-4-methoxyphenyl)-1,3-dithian-2-yl]pentanoate

: 1415336-43-4
(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

2: piperidine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With piperidine; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-41-2
methyl 5-(2-(2-acetamido-4-methoxyphenyl)-1,3-dithian-2-yl)pentanoate

: 1415336-43-4
(R)-methyl 5-(2-(2-(2-aminopropanamido)-4-methoxyphenyl)-1,3-dithian-2-l)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / water / 4 h / 40 - 50 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

3: piperidine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

With piperidine; hydrogenchloride; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ol303149k