(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

Base Information

Chemical Name:(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate
CAS No.:1415336-42-3
Molecular Formula:C₃₅H₄₀N₂O₆S₂
Molecular Weight:648.844
Hs Code.:

Synonyms:(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

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Chemical Property of (R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

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Technology Process of (R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

There total 5 articles about (R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415336-56-9
methyl 5-[2-(2-amino-4-methoxyphenyl)-1,3-dithian-2-yl]pentanoate

: 144073-15-4
(9H-fluoren-9-yl)methyl (R)-(1-chloro-1-oxopropan-2-yl)carbamate

: 1415336-42-3
(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 6h; Inert atmosphere;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-37-6
methyl 6-(2-acetamido-4-methoxyphenyl)-6-oxohexanoate

: 1415336-42-3
(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / dichloromethane / 16 h / 20 °C / Inert atmosphere

2: hydrogenchloride / water / 4 h / 40 - 50 °C / Inert atmosphere

3: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

With hydrogenchloride; boron trifluoride diethyl etherate; sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ol303149k

Reference yield:

: 1415336-41-2
methyl 5-(2-(2-acetamido-4-methoxyphenyl)-1,3-dithian-2-yl)pentanoate

: 1415336-42-3
(R)-methyl 5-(2-{2-[2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}propanamido]-4-methoxyphenyl}-1,3-dithian-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 4 h / 40 - 50 °C / Inert atmosphere

2: sodium hydrogencarbonate / water; dichloromethane / 6 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium hydrogencarbonate; In dichloromethane; water;
DOI:10.1021/ol303149k