2-ISOCYANOBENZOPHENONE

Base Information

• Chemical Name: 2-ISOCYANOBENZOPHENONE
• CAS No.: 521270-76-8
• Molecular Formula: C₁₄H₉NO
• Molecular Weight: 207.232
• Mol file: 521270-76-8.mol

Synonyms:(2-isocyanophenyl)(phenyl)methanone

Chemical Property of 2-ISOCYANOBENZOPHENONE

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

2-ISOCYANOBENZOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-ISOCYANOBENZOPHENONE

There total 2 articles about 2-ISOCYANOBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N-(2-benzoylphenyl)-formamide (54567-10-1) → (2-isocyanophenyl)(phenyl)methanone (521270-76-8)

Guidance literature:

With triethylamine; trichlorophosphate; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02582

Reference yield:

(2-aminophenyl)(phenyl)methanone (2835-77-0) → (2-isocyanophenyl)(phenyl)methanone (521270-76-8)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / Heating

2: POCl₃; Et₃N / tetrahydrofuran / 0 °C

With triethylamine; trichlorophosphate; In tetrahydrofuran; toluene;

DOI:10.1016/j.tet.2004.09.069

Reference yield: 98.0%

(3-methoxyphenyl)magnesium bromide (36282-40-3) + (2-isocyanophenyl)(phenyl)methanone (521270-76-8) → 2-(3-methoxyphenyl)-3-phenyl-3H-indol-3-ol (1253396-21-2)

Guidance literature:

(3-methoxyphenyl)magnesium bromide; (2-isocyanophenyl)(phenyl)methanone; In tetrahydrofuran; diethyl ether; at 0 ℃;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; at 0 ℃;

DOI:10.1016/j.tet.2010.08.023

upstream raw materials:

N-(2-benzoylphenyl)-formamide

(2-aminophenyl)(phenyl)methanone

Downstream raw materials:

1-isocyano-2-(2-methoxy-1-phenylethenyl)benzene

2-(4-methylphenyl)-4-phenylquinoline

4-phenyl-2-(thiophen-2-yl)quinoline

(4-phenyl-2-(thiophen-2-yl)quinoline)