Quinoline, 4-phenyl-2-(2-thienyl)-

Base Information

• Chemical Name: Quinoline, 4-phenyl-2-(2-thienyl)-
• CAS No.: 20364-68-5
• Molecular Formula: C19H13NS
• Molecular Weight: 287.385
• ChEMBL ID: CHEMBL3919196
• DSSTox Substance ID: DTXSID50429287
• Nikkaji Number: J463.225G
• Wikidata: Q82242287
• Mol file: 20364-68-5.mol

Synonyms:20364-68-5;4-phenyl-2-thiophen-2-ylquinoline;Quinoline, 4-phenyl-2-(2-thienyl)-;CHEMBL3919196;SCHEMBL16305319;DTXSID50429287;4-phenyl-2-(2-thienyl)quinoline

Chemical Property of Quinoline, 4-phenyl-2-(2-thienyl)-

Chemical Property:

• PSA: 41.13000
• LogP: 5.63030
• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 287.07687059
• Heavy Atom Count: 21
• Complexity: 339

Purity/Quality:

99.0% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CC(=NC3=CC=CC=C32)C4=CC=CS4

Technology Process of Quinoline, 4-phenyl-2-(2-thienyl)-

There total 19 articles about Quinoline, 4-phenyl-2-(2-thienyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

thiophene-2-carbaldehyde (98-03-3) + 2-(1-phenylvinyl)aniline (64097-92-3) → (4-phenyl-2-(thiophen-2-yl)quinoline) (20364-68-5)

Guidance literature:

With iron(III) chloride; In toluene; at 80 ℃; for 3h; Green chemistry;

DOI:10.1002/jccs.201800001

Reference yield: 86.0%

thiophene-2-carbaldehyde (98-03-3) + phenylacetylene (536-74-3) + aniline (62-53-3) → (4-phenyl-2-(thiophen-2-yl)quinoline) (20364-68-5)

Guidance literature:

thiophene-2-carbaldehyde; aniline; In dimethyl sulfoxide; at 60 ℃; for 2h;

phenylacetylene; With iron(III)-acetylacetonate; tetra(n-butyl)ammonium hydroxide; In dimethyl sulfoxide; at 20 ℃;

DOI:10.1055/s-0030-1260305

Reference yield: 85.0%

2-Acetylthiophene (88-15-3,97511-16-5) + (2-aminophenyl)(phenyl)methanol (13209-38-6) → (4-phenyl-2-(thiophen-2-yl)quinoline) (20364-68-5)

Guidance literature:

With potassium hydroxide; In poly(ethylene glycol)-400; at 80 ℃;

DOI:10.1002/jccs.201100404

upstream raw materials:

2-Acetylthiophene

(2-aminophenyl)(phenyl)methanone

(E)-N-phenyl-1-(thiophen-2-yl)methanimine

phenylacetylene

Downstream raw materials:

C₇₆H₄₈Cl₂Ir₂N₄S₄