<6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride

Base Information

• Chemical Name: <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride
• CAS No.: 84449-67-2
• Molecular Formula: C₃₁H₂₉NO₆S*ClH
• Molecular Weight: 580.101

Synonyms:<6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride

Chemical Property of <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

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Technology Process of <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride

There total 8 articles about <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

α-(3-methoxyphenyl-thio)-4-methoxyacetophenone (63675-73-0) → <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride (84449-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / PPA / 1 h / 85 - 90 °C

2: 71 percent / pyridine hydrochloride / 6 h / 220 °C

3: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature

4: AlCl₃ / 1,2-dichloro-ethane / 1 h

With pyridine; dmap; aluminium trichloride; pyridine hydrochloride; In 1,2-dichloro-ethane;

DOI:10.1021/jm00374a021

Reference yield:

6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene (84449-63-8) + 4-[2-(1-pyrrolidinyl)ethoxy]benzoic acid hydrochloride (63675-90-1) → <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride (84449-67-2)

Guidance literature:

With thionyl chloride; aluminium trichloride; In N-methyl-acetamide; ice-water; 1,2-dichloro-ethane;

Reference yield:

3-methoxybenzenethiol (15570-12-4) → <6-acetoxy-2-(4-acetoxyphenyl)benzothien-3-yl><4-<2-(1-pyrrolidinyl)ethoxy>phenyl>methanone hydrochloride (84449-67-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 80.4 percent / KOH / ethanol; H₂O; ethyl acetate / Ambient temperature

2: 69 percent / PPA / 1 h / 85 - 90 °C

3: 71 percent / pyridine hydrochloride / 6 h / 220 °C

4: 97 percent / 4-(dimethylamino)pyridine, pyridine / Ambient temperature

5: AlCl₃ / 1,2-dichloro-ethane / 1 h

With pyridine; dmap; potassium hydroxide; aluminium trichloride; pyridine hydrochloride; In ethanol; water; ethyl acetate; 1,2-dichloro-ethane;

DOI:10.1021/jm00374a021

upstream raw materials:

4-[2-(1-pyrrolidinyl)ethoxy]benzoyl chloride

6-acetoxy-2-(4-acetoxyphenyl)benzo[b]thiophene

3-methoxybenzenethiol

2-(4'-methoxyphenyl)-6-methoxybenzothiophene

Downstream raw materials:

6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-pyrrolidinoethoxy)benzoyl]benzo[b]thiophene

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