3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Base Information

Chemical Name:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde
CAS No.:1132941-18-4
Molecular Formula:C₁₆H₂₀N₂O₄
Molecular Weight:304.346
Hs Code.:

Synonyms:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

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Chemical Property of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

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Technology Process of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

There total 8 articles about 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1132941-16-2
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

: 1132941-18-4
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:: 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid; With thionyl chloride; for 2h; Heating / reflux;

With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -78 ℃; for 2h;

With hydrogenchloride; water; In tetrahydrofuran; at -78 ℃; for 2h;

Reference yield: 96.0%

: 1132945-26-6
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2methoxybenzoylchloride

: 1132941-18-4
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132941-18-4
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: nitric acid; acetic acid / 2.5 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: iron; ammonium chloride / methanol; water / 1 h / Reflux

4: toluene / 24 h / Reflux

5: acetic acid / 18.5 h / 120 °C

6: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

7: thionyl chloride / 1 h / Reflux

8: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 2 h / -78 °C

With thionyl chloride; nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; lithium tri-t-butoxyaluminum hydride; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; acetone; toluene;
DOI:10.1021/acs.jmedchem.7b01630