3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

Base Information

Chemical Name:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid
CAS No.:1132941-16-2
Molecular Formula:C₁₆H₂₀N₂O₅
Molecular Weight:320.345
Hs Code.:

Synonyms:3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

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Chemical Property of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

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Technology Process of 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

There total 6 articles about 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1132941-14-0
methyl 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoate

: 1132941-16-2
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

Guidance literature:: methyl 3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoate; With methanol; sodium hydroxide; water; In tetrahydrofuran; for 12h;

With hydrogenchloride; water; at 100 ℃; for 1.5h;

Reference yield:

: 1132941-00-4
3-tert-butyl-2-methoxy-5-nitrobenzoate

: 1132941-16-2
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: iron; ammonium chloride / methanol; water / 1 h / Reflux

2: toluene / 24 h / Reflux

3: acetic acid / 18.5 h / 120 °C

4: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

With iron; ammonium chloride; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; toluene;
DOI:10.1021/acs.jmedchem.7b01630

Reference yield:

: 15018-03-8
methyl 3,5‐di‐tert-butyl‐2‐hydroxybenzoate

: 1132941-16-2
3-tert-butyl-5-(2,4-dioxotetrahydropyrimidin-1(2H)-yl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; acetic acid / 2.5 h / 20 °C

2: potassium carbonate / acetone / Reflux

3: iron; ammonium chloride / methanol; water / 1 h / Reflux

4: toluene / 24 h / Reflux

5: acetic acid / 18.5 h / 120 °C

6: sodium hydroxide / methanol; water; tetrahydrofuran / 12 h / 20 °C

With nitric acid; iron; potassium carbonate; ammonium chloride; acetic acid; sodium hydroxide; In tetrahydrofuran; methanol; water; acetic acid; acetone; toluene;
DOI:10.1021/acs.jmedchem.7b01630