5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Base Information

Chemical Name:5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole
CAS No.:1612254-49-5
Molecular Formula:C₃₀H₂₆N₆O
Molecular Weight:486.576
Hs Code.:

Synonyms:5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

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Chemical Property of 5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

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Technology Process of 5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

There total 8 articles about 5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 129012-05-1
2-(4-hydroxyphenyl)-3H-benzoimidazole-5-carbaldehyde

: 23617-81-4
4-(4-phenyl-piperazin-1-yl)-benzene-1,2-diamine

: 1612254-49-5
5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Guidance literature:: With sodium metabisulfite; In ethanol; water; for 24h; Reflux;
DOI:10.1021/jm5003028

Reference yield:

: 5443-33-4
N-(5-chloro-2-nitrophenyl)acetamide

: 1612254-49-5
5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dimethyl sulfoxide / 120 °C

2: sulfuric acid / 80 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 °C / 2068.65 Torr

4: sodium metabisulfite / water; ethanol / 24 h / Reflux

With sodium metabisulfite; sulfuric acid; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm5003028

Reference yield:

: 92-54-6
4-phenyl-1-piperazine

: 1612254-49-5
5-(4-phenylpiperazin-1-yl)-2-[2′-(4-hydroxyphenyl)-5′-benzimidazolyl]benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dimethyl sulfoxide / 120 °C

2: sulfuric acid / 80 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate; methanol / 20 °C / 2068.65 Torr

4: sodium metabisulfite / water; ethanol / 24 h / Reflux

With sodium metabisulfite; sulfuric acid; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate;
DOI:10.1021/jm5003028