(RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone

Base Information

• Chemical Name: (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone
• CAS No.: 867296-78-4
• Molecular Formula: C₂₄H₂₆O₇
• Molecular Weight: 426.466
• Mol file: 867296-78-4.mol

Synonyms:(RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone

Chemical Property of (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone

There total 2 articles about (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromomethyl-4-methoxybenzoic acid ethyl ester (56427-63-5) + ethyl 5-methoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (16425-82-4) → (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone (867296-78-4)

Guidance literature:

ethyl 5-methoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃;

2-bromomethyl-4-methoxybenzoic acid ethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 44h;

DOI:10.1021/ja054322k

Reference yield:

ethyl 4-methoxy-2-methylbenzoate (56427-62-4) → (RS)-2-ethoxycarbonyl-2-(2-(ethoxycarbonyl)-5-methoxybenzyl)-5-methoxy-1-indanone (867296-78-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-bromosuccinimide; dibenzoyl peroxide / CCl₄ / Heating

2.1: NaH / dimethylformamide / 60 °C

2.2: 1.61 g / dimethylformamide / 44 h / 60 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja054322k

upstream raw materials:

2-bromomethyl-4-methoxybenzoic acid ethyl ester

ethyl 5-methoxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate

ethyl 4-methoxy-2-methylbenzoate