2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Base Information

Chemical Name:2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester
CAS No.:905911-92-4
Molecular Formula:C₅₄H₉₀N₂O₁₇P₂
Molecular Weight:1101.26
Hs Code.:

Synonyms:2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

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Chemical Property of 2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

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Technology Process of 2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

There total 4 articles about 2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 688021-88-7
1,2-di-O-octanoyl-3-O-benzyl-sn-glycerol

: 905911-92-4
2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / hydrogen; acetic acid / Pd-C / ethanol; ethyl acetate / 18 h / 2068.59 Torr

2.1: ethyldiisopropylamine / CH₂Cl₂ / 1 h / 20 °C

3.1: 1H-tetrazole / CH₂Cl₂; acetonitrile / 3 h / 20 °C

3.2: 5.6 g / hydrogen peroxide / CH₂Cl₂; acetonitrile / 2.25 h / -40 - 20 °C

With 1H-tetrazole; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2006.04.071

Reference yield:

: 111-64-8
n-octanoic acid chloride

: 905911-92-4
2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 50 percent / pyridine; 4-(dimethylamino)pyridine / 48 h / 55 °C

2.1: 94 percent / hydrogen; acetic acid / Pd-C / ethanol; ethyl acetate / 18 h / 2068.59 Torr

3.1: ethyldiisopropylamine / CH₂Cl₂ / 1 h / 20 °C

4.1: 1H-tetrazole / CH₂Cl₂; acetonitrile / 3 h / 20 °C

4.2: 5.6 g / hydrogen peroxide / CH₂Cl₂; acetonitrile / 2.25 h / -40 - 20 °C

With pyridine; 1H-tetrazole; dmap; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1016/j.tet.2006.04.071

Reference yield:

: 243652-05-3
Octanoic acid (R)-2-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-1-octanoyloxymethyl-ethyl ester

: 14690-00-7
2-O-benzylglycerol

: 905911-92-4
2-O-benzyl-1,3-bis[(1,2-di-O-octanoyl-sn-glycero-3)-phosphoryl]glycerol di(2-cyanoethyl) ester

Guidance literature:: Octanoic acid (R)-2-[(2-cyano-ethoxy)-diisopropylamino-phosphanyloxy]-1-octanoyloxymethyl-ethyl ester; 2-O-benzylglycerol; With 1H-tetrazole; In dichloromethane; acetonitrile; at 20 ℃; for 3h;

With dihydrogen peroxide; In dichloromethane; acetonitrile; at -40 - 20 ℃; for 2.25h;
DOI:10.1016/j.tet.2006.04.071