5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

Base Information

Chemical Name:5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one
CAS No.:1044749-15-6
Molecular Formula:C₁₃H₁₂ClFN₂OS
Molecular Weight:298.768
Hs Code.:

Synonyms:5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

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Technology Process of 5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

There total 1 articles about 5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75279-55-9
6-chloro-2-fluorophenylacetonitrile

: 1044749-15-6
5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: zinc / tetrahydrofuran / 0.5 h / Reflux

1.2: 1.5 h / 20 °C

2.1: potassium ethoxide / ethanol / Reflux

2.2: pH 5 - 6

With potassium ethoxide; zinc; In tetrahydrofuran; ethanol;
DOI:10.1134/S1070428010110151

Reference yield: 79.0%

: 1044749-15-6
5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1044748-88-0
C₂₁H₁₇ClF₂N₂O₂S

Guidance literature:: With sodium methylate; In methanol; at 20 ℃;
DOI:10.1021/jm800340w

Reference yield: 75.0%

: 1044749-15-6
5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one

: 74-88-4
methyl iodide

: 1242134-33-3
2-(methylsulfanyl)-6-(2-fluoro-6-chlorobenzyl)-5-ethylpyrimidin-4(3H)-one

Guidance literature:: 5-ethyl-2-thioxo-6-(2-fluoro-6-chlorobenzyl)-2,3-dihydropyrimidin-4(1H)-one; methyl iodide; With potassium hydroxide; In ethanol;

With acetic acid; In ethanol; water; pH=5; regioselective reaction;
DOI:10.1134/S1070428010110151