7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

Base Information

Chemical Name:7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone
CAS No.:144128-53-0
Molecular Formula:C₂₈H₂₉ClF₃N₃O₂
Molecular Weight:532.005
Hs Code.:

Synonyms:7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

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Chemical Property of 7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

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Technology Process of 7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

There total 5 articles about 7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3529-08-6
1-(3-aminopropyl)piperidine

: 53966-34-0
3-(4-trifluoromethylphenyl)-7-chloro-10-hydroxy-3,4-dihydroacridine-1,9(2H,10H)-dione

: 144128-53-0
7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

Guidance literature:: In ethanol; for 1.5h; Heating;
DOI:10.1021/jm00097a001

Reference yield:

: 455-19-6
4-Trifluoromethylbenzaldehyde

: 144128-53-0
7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

Guidance literature:: Multi-step reaction with 6 steps

1: 32 percent / 50percent aq. NaOH / 72 h / Ambient temperature

2: EtONa / ethanol / 6 h / Heating

3: 2 N NaOH / 2 h / Heating

4: 5 N H₂SO₄ / 4.5 h / Heating

5: 55 percent / concd HCl, glacial AcOH / 4 h / 85 °C

6: 95 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; sodium hydroxide; sulfuric acid; sodium ethanolate; acetic acid; In ethanol;
DOI:10.1021/jm00097a001

Reference yield:

: 55579-69-6
5-<4-(trifluoromethyl)phenyl>-1,3-cyclohexanedione

: 144128-53-0
7-chloro-1,3,4,10-tetrahydro-10-hydroxy-1-<<3-(1-piperidinyl)propyl>imino>-3-<4-(trifluoromethyl)phenyl>-9(2H)-acridinone

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / concd HCl, glacial AcOH / 4 h / 85 °C

2: 95 percent / ethanol / 1.5 h / Heating

With hydrogenchloride; acetic acid; In ethanol;
DOI:10.1021/jm00097a001