{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Base Information

Chemical Name:{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol
CAS No.:82599-08-4
Molecular Formula:C₃₃H₅₆ClNO₇Si
Molecular Weight:642.349
Hs Code.:

{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Synonyms:{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Suppliers and Price of {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

There total 41 articles about {(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 82599-07-3
(2E,9E,11E)-(4S,5S,8R)-5-(tert-Butyl-dimethyl-silanyloxy)-13-(4-chloro-3-methoxy-5-methylamino-phenyl)-7,7,8-trimethoxy-2,4,12-trimethyl-trideca-2,9,11-trien-1-ol

: 82599-08-4
{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: With titanium(IV) isopropylate; tert.-butylhydroperoxide; In dichloromethane; at -20 ℃; for 1.5h;
DOI:10.1021/ja00382a065

Reference yield:

: 82599-00-6
(2-Chloro-5-iodomethyl-3-methoxy-phenyl)-methyl-carbamic acid methyl ester

: 82599-08-4
{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 10 steps

2: ozone / -78 °C

3: NaBH₄ / ethanol / 0.5 h / 0 °C

4: PBr₃, LiBr, collidine / diethyl ether; tetrahydrofuran

5: nitromethane

6: t-BuLi / tetrahydrofuran; dimethylformamide / -63 °C

7: 78 percent / tetrahydrofuran / -63 deg C -> room temperature

8: H₂O, AcOH / tetrahydrofuran / 48 h / -10 °C

9: 1.) NaBH₄, 2.) KOH, EtOH / 1.) MeOH, 0 deg C, 15 min, 2.) reflux, 22 h

10: 70 percent / t-BuOOH, Ti(O-i-Pr)4 / CH₂Cl₂ / 1.5 h / -20 °C

With titanium(IV) isopropylate; 2,3,5-trimethyl-pyridine; tert.-butylhydroperoxide; potassium hydroxide; sodium tetrahydroborate; ethanol; water; tert.-butyl lithium; phosphorus tribromide; ozone; acetic acid; lithium bromide; In tetrahydrofuran; diethyl ether; nitromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00382a065

Reference yield:

: 67705-17-3
[2-Chloro-3-methoxy-5-((E)-2-methyl-4-oxo-but-2-enyl)-phenyl]-methyl-carbamic acid methyl ester

: 82599-08-4
{(2S,3S)-3-[(6E,8E)-(1S,2S,5R)-2-(tert-Butyl-dimethyl-silanyloxy)-10-(4-chloro-3-methoxy-5-methylamino-phenyl)-4,4,5-trimethoxy-1,9-dimethyl-deca-6,8-dienyl]-2-methyl-oxiranyl}-methanol

Guidance literature:: Multi-step reaction with 8 steps

1: NaBH₄ / ethanol / 0.5 h / 0 °C

2: PBr₃, LiBr, collidine / diethyl ether; tetrahydrofuran

3: nitromethane

4: t-BuLi / tetrahydrofuran; dimethylformamide / -63 °C

5: 78 percent / tetrahydrofuran / -63 deg C -> room temperature

6: H₂O, AcOH / tetrahydrofuran / 48 h / -10 °C

7: 1.) NaBH₄, 2.) KOH, EtOH / 1.) MeOH, 0 deg C, 15 min, 2.) reflux, 22 h

8: 70 percent / t-BuOOH, Ti(O-i-Pr)4 / CH₂Cl₂ / 1.5 h / -20 °C

With titanium(IV) isopropylate; 2,3,5-trimethyl-pyridine; tert.-butylhydroperoxide; potassium hydroxide; sodium tetrahydroborate; ethanol; water; tert.-butyl lithium; phosphorus tribromide; acetic acid; lithium bromide; In tetrahydrofuran; diethyl ether; nitromethane; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00382a065