2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol

Base Information

Chemical Name:2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol
CAS No.:179096-61-8
Molecular Formula:C₁₇H₃₁NO₂Si
Molecular Weight:309.524
Hs Code.:
DSSTox Substance ID:DTXSID401129926

Synonyms:DTXSID401129926;2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol;179096-61-8

Suppliers and Price of 2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:309.212405766
Heavy Atom Count:21
Complexity:315

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=CC=C(C=C1)C(C)(C)NCCO

Technology Process of 2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol

There total 4 articles about 2-[[1-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl]-1-methylethyl]amino]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-89-8
4-Isopropylphenol

: 179096-61-8
2-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-methyl-ethylamino}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 3 h / 25 °C

2: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

3: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

4: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

With 1H-imidazole; trimethylsilylazide; hydrogen; lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960092w

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 179096-61-8
2-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-methyl-ethylamino}-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 3 h / 25 °C

2: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

3: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

4: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

With 1H-imidazole; trimethylsilylazide; hydrogen; lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm960092w

Reference yield:

: 158978-08-6
tert-butyl(4-isopropylphenoxy)dimethylsilane

: 179096-61-8
2-{1-[4-(tert-Butyl-dimethyl-silanyloxy)-phenyl]-1-methyl-ethylamino}-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1: azidotrimethylsilane, DDQ / CHCl₃ / 3 h / 25 °C

2: H₂ / 5percent Pd/BaSO₄ / ethanol / 5 h / 25 °C / 760 Torr

3: 1.) LiClO₄ / 1.) THF, 0 deg C, 10 min, 2.) THF, CH₃CN, RT, 3 h

With trimethylsilylazide; hydrogen; lithium perchlorate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; Pd-BaSO₄; In ethanol; chloroform;
DOI:10.1021/jm960092w