(Z)-Cbz-ΔGlu(OSu)-OMe

Base Information

• Chemical Name: (Z)-Cbz-ΔGlu(OSu)-OMe
• CAS No.: 130680-61-4
• Molecular Formula: C₁₈H₁₈N₂O₈
• Molecular Weight: 390.35
• Mol file: 130680-61-4.mol

Synonyms:(Z)-Cbz-ΔGlu(OSu)-OMe

Chemical Property of (Z)-Cbz-ΔGlu(OSu)-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-Cbz-ΔGlu(OSu)-OMe

There total 2 articles about (Z)-Cbz-ΔGlu(OSu)-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) + Cbz-ΔGlu-OMe (130680-59-0) → (Z)-Cbz-ΔGlu(OSu)-OMe (130680-61-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1248/cpb.38.2020

Reference yield:

methyl γ-methyl-α-(N-benzyloxycarbonyl)-α-dehydroglutamate (96658-30-9) → (Z)-Cbz-ΔGlu(OSu)-OMe (130680-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / aq. LiOH / H₂O; dioxane / 3 h

2: 100 percent / DCC / tetrahydrofuran

With lithium hydroxide; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1248/cpb.38.2020

Reference yield: 94.0%

(Z)-Cbz-ΔGlu(OSu)-OMe (130680-61-4) + tert-butylamine (75-64-9) → Cbz-ΔGln(tert-Bu)-OMe (130680-65-8)

Guidance literature:

In 1,2-dimethoxyethane; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.38.2020

upstream raw materials:

1-hydroxy-pyrrolidine-2,5-dione

Cbz-ΔGlu-OMe

methyl γ-methyl-α-(N-benzyloxycarbonyl)-α-dehydroglutamate

Downstream raw materials:

Cbz-ΔGln-OMe

Cbz-ΔGln(tert-Bu)-OMe

Refernces