N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Base Information

Chemical Name:N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide
CAS No.:1416335-22-2
Molecular Formula:C₂₅H₁₉F₂N₅O₅S₂
Molecular Weight:571.585
Hs Code.:

Synonyms:N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Chemical Property of N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

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Technology Process of N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

There total 7 articles about N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 10.21%

: 64-18-6
formic acid

: 1083326-73-1
N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide

: 1416337-05-7
6-iodo-1-(phenylsulfonyl)-1H-benzo[d]imidazol-2-amine

: 1416335-22-2
N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-2,4-difluorobenzenesulfonamide; 6-iodo-1-(phenylsulfonyl)-1H-benzo[d]imidazol-2-amine; With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 130 ℃; for 0.333333h; Microwave irradiation;

formic acid; In water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1416335-22-2
N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile; water / 4 h / 20 °C

2: N-iodo-succinimide / acetic acid / 16 h / 55 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation

With N-iodo-succinimide; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetic acid; acetonitrile; 3: Suzuki Coupling;

Reference yield:

: 934-32-7
1H-benzimidazol-2-amine

: 1416335-22-2
N-[5-[2-amino-1-(phenylsulfonyl)-1H-benzimidazol-6-yl]-2-(methyloxy)-3-pyridinyl]-2,4-difluorobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile; water / 4 h / 20 °C

2: N-iodo-succinimide / acetic acid / 16 h / 55 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 130 °C / Microwave irradiation

With N-iodo-succinimide; potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; acetic acid; acetonitrile; 3: Suzuki Coupling;