5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

Base Information

Chemical Name:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester
CAS No.:1616924-47-0
Molecular Formula:C₃₁H₃₆N₂O₆
Molecular Weight:532.637
Hs Code.:

Synonyms:5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

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Chemical Property of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

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Technology Process of 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

There total 7 articles about 5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.09%

: 1616924-46-9
2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

: (E)-2-benzyloxy-3-hydroxybut-2-enedioic acid 4-tert-butyl ester 1-methyl ester

: 1616924-47-0
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

Guidance literature:: With sodium methylate; In methanol; at 0 - 20 ℃; for 16h;

Reference yield:

: 60356-11-8
cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester

: 1616924-47-0
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

1.2: 1 h / -78 - -30 °C

2.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

2.2: 16 h / 20 °C

3.1: hydroxylamine / ethanol; water / 16 h / 60 °C

4.1: 16 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

6.1: sodium methylate / methanol / 16 h / 0 - 20 °C

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium methylate; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1616924-47-0
5-benzyloxy-6-hydroxy-2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-ylmethyl)pyrimidine-4-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; ammonium acetate / toluene / 16 h / Dean-Stark; Reflux

2.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

2.2: 1 h / -78 - -30 °C

3.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

3.2: 16 h / 20 °C

4.1: hydroxylamine / ethanol; water / 16 h / 60 °C

5.1: 16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

7.1: sodium methylate / methanol / 16 h / 0 - 20 °C

With copper(l) iodide; palladium 10% on activated carbon; ammonium acetate; hydrogen; hydroxylamine; sodium methylate; acetic acid; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide; toluene;