tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol

Base Information

• Chemical Name: tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol
• CAS No.: 398136-44-2
• Molecular Formula: C₂₅H₂₇NO₄
• Molecular Weight: 405.494
• Mol file: 398136-44-2.mol

Synonyms:tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol

Chemical Property of tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol

There total 4 articles about tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

benzophenone (119-61-9) + tert-butyl 2-methoxyphenylcarbamate (154150-18-2) → tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol (398136-44-2) + 8-methoxy-4,4-diphenyl-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one

Guidance literature:

tert-butyl 2-methoxyphenylcarbamate; With carbon dioxide; tert.-butyl lithium; In diethyl ether; acetonitrile; pentane; at -45 - -20 ℃; for 3h; Schlenk technique;

benzophenone; With carbon dioxide; In diethyl ether; ethanol; acetonitrile; pentane; at -78 - 20 ℃; for 18h; Overall yield = 75 percent; Overall yield = 12.6 g; Schlenk technique;

DOI:10.1002/chem.202100616

Reference yield: 46.0%

benzophenone (119-61-9) + tert-butyl 2-methoxyphenylcarbamate (154150-18-2) → tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol (398136-44-2) + N-(diphenylmethylene)-N-(2-methoxyphenyl)amine (73939-13-6)

Guidance literature:

tert-butyl 2-methoxyphenylcarbamate; With tert.-butyl lithium; In diethyl ether; pentane; at -20 ℃; for 3h;

benzophenone; In diethyl ether; pentane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/ol016966c

Reference yield:

2-methoxy-phenylamine (90-04-0) → tert-butyl-((2-hydroxydiphenylmethyl)-6-methoxyphenyl)carbamateol (398136-44-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / tetrahydrofuran / 30 h / Heating

2.1: t-BuLi / diethyl ether; pentane / 3 h / -20 °C

2.2: 46 percent / diethyl ether; pentane / -78 - 20 °C

With tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane;

DOI:10.1021/ol016966c

upstream raw materials:

benzophenone

tert-butyl 2-methoxyphenylcarbamate

2-methoxy-phenylamine

Downstream raw materials:

3-acryloyl-4-(diphenylmethyl)-1,3-benzoxazol-2(3H)-one

4-(diphenylmethyl)-1,3-benzoxazol-2(3H)-one

2-amino-3-(diphenylmethyl)phenol

2-(diphenylmethyl)-6-methoxyaniline