(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Base Information

Chemical Name:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide
CAS No.:1246766-15-3
Molecular Formula:C₂₅H₂₉N₅O₂
Molecular Weight:431.538
Hs Code.:

Synonyms:(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Suppliers and Price of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

There total 9 articles about (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1246765-54-7
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid

: 124-40-3
dimethyl amine

: 1246766-15-3
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Guidance literature:: (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; for 0.333333h;

dimethyl amine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1021/jm500206r

Reference yield: 71.0%

: 1246766-15-3
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Guidance literature:

Reference yield:

: 1246765-25-2
methyl 6-(3-cyclopentylacryloyl)-2-methoxynicotinate

: 1246766-15-3
(R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxy-N,N-dimethylnicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 3 h / 80 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: chiralpak AD-H / methanol / Resolution of racemate; Supercritical conditions

3.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 0.33 h

3.2: 12 h / 20 °C

With sodium ethanolate; 1,1'-carbonyldiimidazole; In methanol; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm500206r