3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester

Base Information

• Chemical Name: 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester
• CAS No.: 70978-11-9
• Molecular Formula: C₁₈H₁₇N₅O₄
• Molecular Weight: 367.364

Synonyms:3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester

Chemical Property of 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester

Chemical Property:

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Technology Process of 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester

There total 5 articles about 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 6-hydroxy-m-toluate (22717-57-3) → 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester (70978-11-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 24 percent / conc. HNO₃, conc. H₂SO₄ / -20 °C

2: 58 percent / H₂ / 5percent Pd/C / ethanol

3: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; sulfuric acid; hydrogen; nitric acid; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

methyl 2-hydroxy-5-methyl-3-nitrobenzoate (67191-44-0) → 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester (70978-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / H₂ / 5percent Pd/C / ethanol

2: pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethanol; dichloromethane;

DOI:10.1021/jm00154a019

Reference yield:

methyl 3-amino-2-hydroxy-5-methylbenzoate (70978-07-3) + 1-benzyl-5-tetrazolecarbonyl chloride (64470-37-7) → 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester (70978-11-9)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 1h; Yield given;

DOI:10.1021/jm00154a019

upstream raw materials:

methyl 3-amino-2-hydroxy-5-methylbenzoate

1-benzyl-5-tetrazolecarbonyl chloride

1-benzyl-1H-tetrazole-5-carboxylic acid potassium salt

methyl 6-hydroxy-m-toluate

Downstream raw materials:

2-hydroxy-5-methyl-3-(1⁽²⁾H-tetrazole-5-carbonylamino)-benzoic acid methyl ester

N-(3-carboxy-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide

2-hydroxy-5-methyl-3-(1⁽²⁾H-tetrazole-5-carbonylamino)-benzoic acid ethyl ester

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