67191-44-0

Usage

Uses

Used in Pharmaceutical Industry:
Methyl 2-hydroxy-5-methyl-3-nitrobenzenecarboxylate is used as an intermediate in the synthesis of pharmaceutical products for its ability to contribute to the development of biologically active compounds. Its unique structure allows it to be a key component in creating new medications.
Used in Agrochemical Industry:
In the agrochemical sector, Methyl 2-hydroxy-5-methyl-3-nitrobenzenecarboxylate is utilized as a precursor in the production of agrochemicals, playing a crucial role in the synthesis of compounds that can be used in pest control and crop protection.
Safety Note:
It is important to handle Methyl 2-hydroxy-5-methyl-3-nitrobenzenecarboxylate with care due to its potential harmful effects if ingested, inhaled, or comes into contact with skin. Proper safety measures should be taken during its use in laboratories and industrial settings to minimize health risks.

Upstream product

• 67-56-1 methanol 
• 59672-93-4 2-hydroxy-5-methyl-3-nitro-benzoic acid 
• 89-56-5 5-Methylsalicylic acid 
• 7664-93-9 sulfuric acid 

Downstream Products

• 1228005-47-7 (E)-3-(2-chloro-6-ethoxyquinolin-3-yl)-1-(2-hydroxy-5-methyl-3-nitrophenyl)prop-2-en-1-one 
• 70978-44-8 N,N-dimethyl-2-hydroxy-5-methyl-3-nitrobenzamide 
• 70978-09-5 3-Amino-2-hydroxy-5-methyl-N,N-dimethyl-benzamid 
• 123040-88-0 4,6-Dimethyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid 
• 141761-86-6 6-Methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid methyl ester 
• 103454-39-3 N-(3-carboxy-2-hydroxy-5-methylphenyl)-1H-tetrazole-5-carboxamide 
• 70978-11-9 3-(1-benzyl-1H-tetrazole-5-carbonylamino)-2-hydroxy-5-methyl-benzoic acid methyl ester 
• 70977-55-8 2-hydroxy-5-methyl-3-(1⁽²⁾H-tetrazole-5-carbonylamino)-benzoic acid methyl ester 
• 863226-23-7 2-methoxy-3-(2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoylamino)-5-methyl-benzoic acid methyl ester 
• 863226-22-6 2-methoxy-3-{2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoylamino}-5-methyl-benzoic acid methyl ester 
• 863226-21-5 2-methoxy-3-[2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoylamino]-5-methyl-benzoic acid methyl ester 
• 863226-20-4 2-methoxy-3-(2-methoxy-5-methyl-3-nitro-benzoylamino)-5-methyl-benzoic acid methyl ester 
• 863226-28-2 3-(3-amino-2-methoxy-5-methyl-benzoylamino)-2-methoxy-5-methyl-benzoic acid methyl ester 
• 858848-07-4 2-methoxy-5-methyl-3-nitrobenzoic acid 

Relevant academic research and scientific papers

EQUILIBRATIVE NUCLEOSIDE TRANSPORTER ENT1 INHIBITORS

The present invention is related to novel compounds of formula (I) having equilibrative nucleoside transporter ENTl inhibiting properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment of diseases linked to the inhibition of ENTl receptors in animals, in particular humans.

Hydrogen-bonding-induced oligoanthranilamide foldamers. Synthesis, characterization, and complexation for aliphatic ammonium ions

The self-assembly of a novel series of intramolecular hydrogen bonding-driven foldamers have been described. Five linear aromatic amide oligomers 1-5, which bear two to six repeating benzoyl amide subunits, respectively, have been prepared by continuous amide-coupling reactions. The existence of three-centered hydrogen bonds in the oligomers and consequently, the folding conformation of the oligomers in the solid state and solution have been proved by the X-ray analysis (for 2) and the 1H NMR and IR experiments. Molecular modeling reveals a planar and rigid conformation for the oligomers and a cavity of 0.86 nm in diameter for 6-mer 5. Fluorescent and 1H NMR experiments have demonstrated that the new aromatic oligo-amide foldamers can bind primary and secondary alkyl ammonium ions in chloroform and the associated binding constants have been determined. It is revealed that 5-mer 4 exhibits the largest binding ability. A face-to-face binding mode has been proposed for the complexes.

2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof

New tetrazole derivatives of the general formula: STR1 [wherein R1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: (wherein R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.