6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Base Information

Chemical Name:6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one
CAS No.:960402-40-8
Molecular Formula:C₁₉H₁₁BrClNOS
Molecular Weight:416.725
Hs Code.:

Synonyms:6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

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Chemical Property of 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

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Technology Process of 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

There total 9 articles about 6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

: 960289-27-4
2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

: 5467-74-3
4-Bromophenylboronic acid

: 960402-40-8
6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Guidance literature:: With pyridine; triethylamine; copper diacetate; In dichloromethane; at 20 ℃; for 48h; Molecular sieve;

Reference yield:

: 24065-33-6
5-Chlorothiophene-2-carboxylic acid

: 960402-40-8
6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride / ethanol / 0.58 h / Heating / reflux

2: water; trifluoroacetic acid / 4 h

3: trifluorormethanesulfonic acid / 2 h / 95 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

With pyridine; trifluorormethanesulfonic acid; water; potassium carbonate; triethylamine; trifluoroacetic acid; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(ll) dichloride; copper diacetate; In ethanol; dichloromethane;

Reference yield:

: 5650-52-2
4,5-dihydro-6H-cyclopenta[b]thiophen-6-one

: 960402-40-8
6-(4-bromo-phenyl)-2-(4-chloro-phenyl)-6H-thieno[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2: bromine; acetic acid / 1 h / 0 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 85 °C

4: pyridine; triethylamine / copper diacetate / dichloromethane / 48 h / 20 °C / Molecular sieve

With pyridine; hydroxylamine hydrochloride; bromine; sodium acetate; sodium carbonate; acetic acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper diacetate; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water;