2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde

Base Information

Chemical Name:2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde
CAS No.:163923-19-1
Molecular Formula:C32H39 N O4
Molecular Weight:501.666
Hs Code.:2922509090
Mol file:163923-19-1.mol

Synonyms:Benzaldehyde,2-hydroxy-5-[[[6-(4-phenylbutoxy)hexyl](phenylmethyl)amino]acetyl]- (9CI)

Suppliers and Price of 2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde

Chemical Property:

PSA：66.84000
LogP:6.48950

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 2-Hydroxy-5-[[[6-(4-phenylbutoxy)hexyl](phenylmethyl)amino]acetyl]-benzaldehyde is used in the synthesis of salmeterol dimer impurity, which is a β2-Adrenergic agonist.

Technology Process of 2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde

There total 5 articles about 2-Hydroxy-5-[[[6,6-(4-phenylbutoxy)hexylbenzyl]amino]acetyl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 115787-50-3
5-(2-bromoacetyl)-2-hydroxybenzaldehyde

: 97664-55-6
N-[6-(4-phenylbutoxy)hexyl]benzenemethanamine

: 163923-19-1
2-hydroxy-5-<<<6,6-(4-phenylbutoxy)hexylbenzyl>amino>acetyl>benzaldehyde

Guidance literature:: In acetonitrile; for 1h; Heating; other solvent;
DOI:10.1080/00397919908086211

Reference yield:

: 629-03-8
1 ,6-dibromohexane

: 163923-19-1
2-hydroxy-5-<<<6,6-(4-phenylbutoxy)hexylbenzyl>amino>acetyl>benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaH / tetrahydrofuran / 7 h / Ambient temperature

2: 70 percent / Et₃N, NaI / dimethylsulfoxide / 17 h / Ambient temperature

3: 71 percent / acetonitrile / 1 h / Heating; other solvent

With sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1080/00397919908086211

Reference yield:

: 3360-41-6
4-phenyl-butan-1-ol

: 163923-19-1
2-hydroxy-5-<<<6,6-(4-phenylbutoxy)hexylbenzyl>amino>acetyl>benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / NaH / tetrahydrofuran / 7 h / Ambient temperature

2: 70 percent / Et₃N, NaI / dimethylsulfoxide / 17 h / Ambient temperature

3: 71 percent / acetonitrile / 1 h / Heating; other solvent

With sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile;
DOI:10.1080/00397919908086211