2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

Base Information

Chemical Name:2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde
CAS No.:151323-48-7
Molecular Formula:C₄₂H₃₆N₆O
Molecular Weight:640.787
Hs Code.:

2-<N-propyl-N-<<2'-<2-(triphenylmethyl)-2H-tetrazol-5-yl>biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

Synonyms:2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

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Chemical Property of 2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

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Technology Process of 2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

There total 6 articles about 2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 151322-73-5
3-(hydroxymethyl)-2-biphenyl-4-yl>methyl>amino>pyridine

: 151323-48-7
2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

Guidance literature:: With manganese(IV) oxide; for 20h; Ambient temperature;
DOI:10.1021/jm00070a012

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 151323-48-7
2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: 0.33 h / Heating

2: 68 percent / ethanol / 6 h / 100 °C

3: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

4: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

5: 96 percent / MnO₂ / 20 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; manganese(IV) oxide; lithium aluminium tetrahydride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol;
DOI:10.1021/jm00070a012

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 151323-48-7
2-biphenyl-4-yl>methyl>amino>pyridine-3-carboxaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / benzene / 3 h / Heating

2: 0.33 h / Heating

3: 68 percent / ethanol / 6 h / 100 °C

4: 1.) 1,3-dimethyl-3,4,5,6-tetrahydro-2-pyrimidinone, LiN(TMS)2 / 1.) THF, 0 deg C, 10 min, 2.) THF, RT, 90 min

5: 95 percent / LiAlH₄ / tetrahydrofuran / 2 h / 0 °C

6: 96 percent / MnO₂ / 20 h / Ambient temperature

With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; manganese(IV) oxide; lithium aluminium tetrahydride; thionyl chloride; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; benzene;
DOI:10.1021/jm00070a012