1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

Base Information

Chemical Name:1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl
CAS No.:532987-02-3
Molecular Formula:C₂₃H₄₂N₂O₄SSi
Molecular Weight:470.749
Hs Code.:

Synonyms:1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

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Chemical Property of 1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

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Technology Process of 1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

There total 11 articles about 1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 124-63-0
methanesulfonyl chloride

: 532987-03-4
2-(3-aminophenyl)-1-(tert-butyldimethylsilyloxy)-2-(octanoylamino)ethyl

: 532987-02-3
1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

Guidance literature:: In pyridine; at 0 ℃; for 0.5h;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 130697-96-0
methyl amino(3-hydroxyphenyl)acetate

: 532987-02-3
1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 9 steps

1: 88 percent / NaHCO₃ / tetrahydrofuran / 0.5 h / 0 °C

2: K₂CO₃ / acetone / 8 h / Heating

3: 79 percent / LiBH₄ / tetrahydrofuran / 18 h / 0 - 20 °C

4: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

5: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

6: 100 percent / pyridine / 1 h / 0 °C

7: 6.10 g / Cs₂CO₃; Pd(OAc)2; (+/-)-BINAP / toluene / 20 h / 80 °C

8: 36 percent / AcONa; NH₂OH*HCl / methanol / 0.5 h / 20 °C

9: 100 percent / pyridine / 0.5 h / 0 °C

With 1H-imidazole; palladium diacetate; lithium borohydride; hydroxylamine hydrochloride; hydrogen; sodium acetate; sodium hydrogencarbonate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0968-0896(02)00381-4

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 532987-02-3
1-(tert-butyldimethylsilyloxy)-2-[(3-methylsulfonylamino)phenyl]-2-(octanoylamino)ethyl

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / imidazole / dimethylformamide / 18 h / 0 °C

2: 100 percent / H₂ / 10 percent Pd-C / methanol / 2 h / 20 °C / atmospheric pressure

3: 100 percent / pyridine / 1 h / 0 °C

4: 6.10 g / Cs₂CO₃; Pd(OAc)2; (+/-)-BINAP / toluene / 20 h / 80 °C

5: 36 percent / AcONa; NH₂OH*HCl / methanol / 0.5 h / 20 °C

6: 100 percent / pyridine / 0.5 h / 0 °C

With 1H-imidazole; palladium diacetate; hydroxylamine hydrochloride; hydrogen; sodium acetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium on activated charcoal; In pyridine; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0968-0896(02)00381-4