N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

Base Information

Chemical Name:N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide
CAS No.:269402-54-2
Molecular Formula:C₁₉H₃₁Cl₂N₃O
Molecular Weight:388.381
Hs Code.:

Synonyms:N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

Chemical Property:

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Technology Process of N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

There total 11 articles about N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109-55-7
1-amino-3-(dimethylamino)propane

: 305-03-3
chlorambucil

: 269402-54-2
N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

Guidance literature:: chlorambucil; With thionyl chloride; In dichloromethane; at 4 ℃; for 16h; Inert atmosphere;

1-amino-3-(dimethylamino)propane; In dichloromethane; at 20 ℃; for 5h; Inert atmosphere;

With sodium hydrogencarbonate; In water;

Reference yield:

: 305-03-3
chlorambucil

: 269402-54-2
N/[3-(dimethylamino)propyl]-4-{4-[bis(2-chloroethyl)amino]phenyl}-butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / CH₂Cl₂ / 4 °C

2: CH₂Cl₂ / 20 °C

With thionyl chloride; In dichloromethane;
DOI:10.1016/j.bmc.2003.09.006