1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine

Base Information

• Chemical Name: 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine
• CAS No.: 355006-70-1
• Molecular Formula: C₁₄H₁₇ClFNO₃
• Molecular Weight: 301.745
• Mol file: 355006-70-1.mol

Synonyms:1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine

Chemical Property of 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine

There total 1 articles about 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methanol (67-56-1) + 1-(4-chlorobenzoyl)-4-piperidone (144947-47-7) → 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine (355006-70-1)

Guidance literature:

With sulfuric acid; Selectfluor; In acetonitrile; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.03.074

Reference yield: 77.0%

1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine (355006-70-1) → C12H11ClFNO2 (355006-67-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.tetlet.2012.03.074

Reference yield:

2-amino-3,6-difluoro benzamidine hydrochloride + 1-(4-chlorobenzoyl)-4,4-dimethoxy-3-fluoropiperidine (355006-70-1) → 1-(4-chlorobenzoyl)-3,5',8'-trifluorospiro[piperidine-4,2'(1'H)-quinazoline]-4'-amine trifluoroacetate

Guidance literature:

In isopropyl alcohol;

upstream raw materials:

methanol

1-(4-chlorobenzoyl)-4-piperidone

Downstream raw materials:

C₁₂H₁₁ClFNO₂