N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Base Information

• Chemical Name: N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide
• CAS No.: 1337930-85-4
• Molecular Formula: C₃₁H₃₆Cl₂N₈O₄
• Molecular Weight: 655.584
• Mol file: 1337930-85-4.mol

Synonyms:N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Chemical Property of N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

There total 5 articles about N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide (1337932-29-2) → N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide (1337930-85-4)

Guidance literature:

N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 18h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid (869663-56-9) → N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide (1337930-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diborane

2.1: dichloromethane / 4 h / 20 °C

2.2: 74.5 h / 20 °C

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

With tetrabutyl ammonium fluoride; diborane; In tetrahydrofuran; dichloromethane;

Reference yield:

2,3-dichloro-1-fluoro-4-nitrobenzene (36556-51-1) → N-(6-(4-(3-(3-tert-butyl-1-(4-(hydroxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide (1337930-85-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 1.5 h / 20 °C

1.2: 16 h

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.2: 42 h / 0 °C / Inert atmosphere

3.1: acetic acid; iron / 1.5 h / 55 °C

4.1: dichloromethane / 4 h / 20 °C

4.2: 74.5 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

With oxalyl dichloride; tetrabutyl ammonium fluoride; iron; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

upstream raw materials:

4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid

2,3-dichloro-1-fluoro-4-nitrobenzene

6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-amine

N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide