N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Base Information

Chemical Name:N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide
CAS No.:1337932-29-2
Molecular Formula:C₃₇H₅₀Cl₂N₈O₄Si
Molecular Weight:769.847
Hs Code.:

N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Synonyms:N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

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Chemical Property of N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

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Technology Process of N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

There total 6 articles about N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 876300-04-8
3-tert-butyl-1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine

: 1337932-22-5
N-(6-(4-amino-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino) butanamide

: 530-62-1
1,1'-carbonyldiimidazole

: 1337932-29-2
N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Guidance literature:: 3-tert-butyl-1-(4-((tert-butyldimethylsilyloxy)methyl)phenyl)-1H-pyrazol-5-amine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 4h;

N-(6-(4-amino-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino) butanamide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 74.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1337932-29-2
N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diborane

2.1: dichloromethane / 4 h / 20 °C

2.2: 74.5 h / 20 °C

With diborane; In dichloromethane;

Reference yield:

: 869663-56-9
4-(5-amino-3-tert-butyl-1H-pyrazol-1-yl)benzoic acid

: 1337932-29-2
N-(6-(4-(3-(3-(tert-butyl)-1-(4-(tert-butyldimethylsilyloxymethyl)phenyl)-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: diborane

2.1: dichloromethane / 4 h / 20 °C

2.2: 74.5 h / 20 °C

With diborane; In dichloromethane;