N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Base Information

Chemical Name:N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide
CAS No.:1337932-21-4
Molecular Formula:C₁₆H₁₇Cl₂N₅O₄
Molecular Weight:414.248
Hs Code.:

Synonyms:N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

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Chemical Property of N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

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Technology Process of N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

There total 2 articles about N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1337932-19-0
6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-amine

: 69954-66-1
4-(dimethylamino)butyric acid hydrochloride

: 1337932-21-4
N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Guidance literature:: 4-(dimethylamino)butyric acid hydrochloride; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 1h;

6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-amine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; at 0 ℃; for 42h; Inert atmosphere;

With sodium hydrogencarbonate; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 36556-51-1
2,3-dichloro-1-fluoro-4-nitrobenzene

: 1337932-21-4
N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 1.5 h / 20 °C

1.2: 16 h

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 1 h / 20 °C

2.2: 42 h / 0 °C / Inert atmosphere

With oxalyl dichloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N,N-dimethyl-formamide; In dichloromethane; dimethyl sulfoxide;

Reference yield: 95.0%

: 1337932-21-4
N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide

: 1337932-22-5
N-(6-(4-amino-2,3-dichlorophenoxy)pyrimidin-4-yl)-4-(dimethylamino) butanamide

Guidance literature:: N-(6-(2,3-dichloro-4-nitrophenoxy)pyrimidin-4-yl)-4-(dimethylamino)butanamide; With iron; acetic acid; at 55 ℃; for 1.5h;

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;