2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester

Base Information

• Chemical Name: 2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester
• CAS No.: 848675-07-0
• Molecular Formula: C₂₁H₂₁NO₄
• Molecular Weight: 351.402
• Mol file: 848675-07-0.mol

Synonyms:2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester

Chemical Property of 2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester

There total 1 articles about 2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-benzoylamino-3-(4-methoxyphenyl)propionic acid prop-2-ynyl ester + methanol (67-56-1) + tetrachloromethane (56-23-5) → 2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester (848675-07-0)

Guidance literature:

2-benzoylamino-3-(4-methoxyphenyl)propionic acid prop-2-ynyl ester; tetrachloromethane; With triethylamine; triphenylphosphine; In acetonitrile; at 20 ℃; for 3h;

methanol; With hydrogenchloride; for 0.25h;

DOI:10.1021/jo0481607

Reference yield:

2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester (848675-07-0) → 2-benzoyl-3-(4-methoxy-benzyl)-6-oxo-2,3,5,6-tetrahydro-1H-[2]pyrindine-3-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaH / dimethylformamide; various solvent(s) / 2 h / 0 °C

2: dimethylsulfoxide; toluene / 4 h / 80 °C

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2: Pauson-Khand reaction;

DOI:10.1021/jo0481607

Reference yield:

2-benzoylamino-2-(4-methoxybenzyl)penta-3,4-dienoic acid methyl ester (848675-07-0) → 2-benzoyl-1-(4-methoxybenzyl)-6-methylene-5-oxo-1,2,3,5,6,6a-hexahydrocyclopenta[c]pyrrole-1-carboxylic acid methyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / NaH / dimethylformamide; various solvent(s) / 2 h / 0 °C

2: dimethylsulfoxide; toluene / 4 h / 80 °C

With sodium hydride; In dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2: Pauson-Khand reaction;

DOI:10.1021/jo0481607

upstream raw materials:

methanol

tetrachloromethane