Methyl (3R)-4-amino-3-hydroxybutanoate

Base Information

Chemical Name:Methyl (3R)-4-amino-3-hydroxybutanoate
CAS No.:916971-31-8
Molecular Formula:C₅H₁₁NO₃
Molecular Weight:133.147
Hs Code.:
DSSTox Substance ID:DTXSID101284503

Synonyms:Methyl (3R)-4-amino-3-hydroxybutanoate;916971-31-8;SCHEMBL7734688;DTXSID101284503;AKOS022191749;EN300-1719539

Suppliers and Price of Methyl (3R)-4-amino-3-hydroxybutanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methyl (3R)-4-amino-3-hydroxybutanoate

Chemical Property:

XLogP3:-1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:133.07389321
Heavy Atom Count:9
Complexity:94.2

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)CC(CN)O
Isomeric SMILES:COC(=O)C[C@H](CN)O

Technology Process of Methyl (3R)-4-amino-3-hydroxybutanoate

There total 1 articles about Methyl (3R)-4-amino-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70681-41-3
(R)-dimethyl malate

: 916971-31-8
(R)-methyl 4-amino-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: borane dimethylsulfide complex; sodium borohydride / tetrahydrofuran / 0 - 20 °C

2: 50 percent / pyridine / 20 °C

3: 84 percent / sodium azide / dimethylformamide / 0.33 h / 80 °C

4: hydrogen; HCl / palladium on carbon / methanol / 2 h / 20 °C / atmospheric pressure

With pyridine; hydrogenchloride; sodium tetrahydroborate; sodium azide; dimethylsulfide borane complex; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.032

Reference yield: 57.0%

: 1-(3,4-dihydroisoquinolin-2(1H)-yl)-4-isocyanobutan-1-one

: 100-52-7
benzaldehyde

: 916971-31-8
(R)-methyl 4-amino-3-hydroxybutanoate

: C₂₆H₃₂N₆O₄

Guidance literature:: (R)-methyl 4-amino-3-hydroxybutanoate; With sodium sulfate; triethylamine; In methanol; for 0.166667h;

benzaldehyde; In methanol; for 0.25h;

1-(3,4-dihydroisoquinolin-2(1H)-yl)-4-isocyanobutan-1-one; With trimethylsilylazide; In methanol; at 20 ℃; for 120h;
DOI:10.1016/j.ejmech.2021.114002

Reference yield: 52.0%

: N-benzyl-4-isocyanobutanamide

: 100-52-7
benzaldehyde

: 916971-31-8
(R)-methyl 4-amino-3-hydroxybutanoate

: C₂₄H₃₀N₆O₄

Guidance literature:: (R)-methyl 4-amino-3-hydroxybutanoate; With sodium sulfate; triethylamine; In methanol; for 0.166667h;

benzaldehyde; In methanol; for 0.25h;

N-benzyl-4-isocyanobutanamide; With trimethylsilylazide; In methanol; at 20 ℃; for 120h;
DOI:10.1016/j.ejmech.2021.114002