4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

Base Information

• Chemical Name: 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile
• CAS No.: 1159983-87-5
• Molecular Formula: C₁₃H₁₂F₄N₂
• Molecular Weight: 272.245
• Mol file: 1159983-87-5.mol

Synonyms:4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

Chemical Property of 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile

There total 2 articles about 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-butyl 4-hydroxy piperidine-1-carboxylate (109384-19-2) → 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile (1159983-87-5)

Guidance literature:

Multi-step reaction with 3 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 1.5 h / -78 - 0 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 25 °C

3: potassium carbonate / dimethyl sulfoxide / 12 h / 100 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; potassium carbonate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

tert-butyl 4-fluoropiperidine-1-carboxylate (178181-55-0) → 4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile (1159983-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / dichloromethane; 1,4-dioxane / 0 - 25 °C

2: potassium carbonate / dimethyl sulfoxide / 12 h / 100 °C

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

Reference yield:

4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)benzonitrile (1159983-87-5) → 4-(4-fluoropiperidin-1-yl)-N'-hydroxy-3-(trifluoromethyl)benzimidamide (1311183-00-2,1311254-27-9)

Guidance literature:

With hydroxylamine; In ethanol; water; at 65 ℃; for 4h;

upstream raw materials:

t-butyl 4-hydroxy piperidine-1-carboxylate

tert-butyl 4-fluoropiperidine-1-carboxylate

Downstream raw materials:

(1R,3S)-3-(4-(3-(4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)phenylamino)cyclopentanecarboxylic acid

4-(4-fluoropiperidin-1-yl)-N'-hydroxy-3-(trifluoromethyl)benzimidamide

5-(4-fluorophenyl)-3-(4-(4-fluoropiperidin-1-yl)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole