1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

Base Information

Chemical Name:1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea
CAS No.:1205744-37-1
Molecular Formula:C₂₄H₂₀FN₅O₂S₂
Molecular Weight:493.586
Hs Code.:

Synonyms:1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

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Chemical Property of 1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

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Technology Process of 1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

There total 8 articles about 1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1205744-38-2
phenyl (6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)carbamate

: 109-85-3
2-methoxyethylamine

: 1205744-37-1
1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 426825-75-4
6-iodoimidazo[1,2-a]pyridine

: 1205744-37-1
1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 80 - 90 °C

2.1: bromine / ethanol; water / 2.5 h / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 190 °C / Microwave irradiation; Sealed tube

4.1: hydrogenchloride / ethanol; water / 29 h / 20 °C / Reflux

5.1: bromine; acetic acid / 18 h / 20 °C

5.2: pH 11

6.1: sodium hydrogencarbonate / water; tetrahydrofuran / 28 h / 20 °C

7.1: tetrahydrofuran / 20 °C

With hydrogenchloride; bromine; sodium hydrogencarbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 1765-93-1
4-fluoroboronic acid

: 1205744-37-1
1-(6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-yl)-3-(2-methoxyethyl)urea

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2.5 h / 80 - 90 °C

2.1: bromine / ethanol; water / 2.5 h / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 190 °C / Microwave irradiation; Sealed tube

4.1: hydrogenchloride / ethanol; water / 29 h / 20 °C / Reflux

5.1: bromine; acetic acid / 18 h / 20 °C

5.2: pH 11

6.1: sodium hydrogencarbonate / water; tetrahydrofuran / 28 h / 20 °C

7.1: tetrahydrofuran / 20 °C

With hydrogenchloride; bromine; sodium hydrogencarbonate; potassium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; water; dimethyl sulfoxide;