Technology Process of 6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-amine
There total 6 articles about 6-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}-1,3-benzothiazol-2-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-{[6-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]sulphanyl}aniline; potassium thioacyanate;
With
bromine; acetic acid;
at 20 ℃;
for 18h;
With
sodium hydroxide;
In
water;
pH=11;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / 80 - 90 °C
2.1: bromine / ethanol; water / 2.5 h / 20 °C
3.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 190 °C / Microwave irradiation; Sealed tube
4.1: hydrogenchloride / ethanol; water / 29 h / 20 °C / Reflux
5.1: bromine; acetic acid / 18 h / 20 °C
5.2: pH 11
With
hydrogenchloride; bromine; sodium hydrogencarbonate; potassium carbonate; acetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; water; dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane; water / 2.5 h / 80 - 90 °C
2.1: bromine / ethanol; water / 2.5 h / 20 °C
3.1: potassium carbonate / dimethyl sulfoxide / 0.25 h / 190 °C / Microwave irradiation; Sealed tube
4.1: hydrogenchloride / ethanol; water / 29 h / 20 °C / Reflux
5.1: bromine; acetic acid / 18 h / 20 °C
5.2: pH 11
With
hydrogenchloride; bromine; sodium hydrogencarbonate; potassium carbonate; acetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
1,4-dioxane; ethanol; water; dimethyl sulfoxide;