ammonium 1-aminoethane-1,1-diphosphonate

Base Information

• Chemical Name: ammonium 1-aminoethane-1,1-diphosphonate
• CAS No.: 124589-58-8
• Molecular Formula: C₂H₉NO₆P₂*H₃N
• Molecular Weight: 222.075
• Mol file: 124589-58-8.mol

Synonyms:ammonium 1-aminoethane-1,1-diphosphonate

Chemical Property of ammonium 1-aminoethane-1,1-diphosphonate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of ammonium 1-aminoethane-1,1-diphosphonate

There total 2 articles about ammonium 1-aminoethane-1,1-diphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

acetamide (60-35-5) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 1-hydroxyethylene-(1,1-diphosphonic acid) (2809-21-4) + 2-amino-2-phosphonocyclohexanecarboxylic acid (102402-46-0) + ammonium 1-aminoethane-1,1-diphosphonate (124589-58-8) + α-amino cyclohexylphosphonic acid (67398-11-2)

Guidance literature:

acetamide; With acetyl chloride; In acetic acid; for 0.25h; Cooling with ice;

ethyl 2-oxocyclohexane carboxylate; In acetic acid; at 20 ℃; Further stages; Cooling with ice;

DOI:10.1080/10426500902737356

Reference yield:

acetamide (60-35-5) + methyl 2-oxocyclopentane-1-carboxylate (10472-24-9,265317-94-0) → 1-hydroxyethylene-(1,1-diphosphonic acid) (2809-21-4) + ammonium 1-aminoethane-1,1-diphosphonate (124589-58-8) + α-amino cyclopentylphosphonic acid (67550-64-5) + 2-Amino-2-phosphono-cyclopentanecarboxylic acid (81746-49-8)

Guidance literature:

acetamide; With acetyl chloride; In acetic acid; for 0.25h; Cooling with ice;

methyl 2-oxocyclopentane-1-carboxylate; With phosphorus trichloride; In acetic acid; at 20 ℃; Further stages; Cooling with ice;

DOI:10.1080/10426500902737356

upstream raw materials:

acetamide

methyl 2-oxocyclopentane-1-carboxylate

ethyl 2-oxocyclohexane carboxylate